After acquiring supplies, the main characters return to the hotel, where the voice contacts them again. The voice identifies himself as Colonel Ryder White, a Banoi Island Defense Force (BIDF) commander, currently trapped in a prison located on Banoi, accessible only through the jungle. He states that due to the characters' immunity, he may be able to obtain an anti-virus to cure his wife of the infection. The group assists a small survivor encampment in the jungle and meet Mowen. Mowen does not know how to get to the prison, but instead takes the players to the location of a secure bio-research facility on the island; the researchers there have been examining a native cannibalistic tribe where they believe the infection may have started from. They affirm that the characters' blood type helps to make them immune to the infection, but at the same time, realize that an anti-virus cannot be created. Under direction by the scientists, the group rescues a native woman, Yerema, who was about to be sacrificed by the tribe. She willingly returns with the group to the laboratory to allow herself to be examined.
After completing tasks for Mowen and returning Jin to her home to put down her infected father, the characters return to the laboratory and find that the infected test subjects had been accidentally released and the scientists wiped out. They rescue Yerema and recover the sample of vaccine that had been created. With Yerema's help, the group, Mowen, and Jin travel to the prison to meet with White. They find that a number of prisoners have survived the infection, and are given their aid in arming themselves to get to White. When they reach an elevator to travel to White the four are informed by Yerema and Jin that Mowen was killed by the infected while helping them get to the elevator, the elevator is suddenly filled with knockout gas. The characters are awoken by Kevin, a technology-savvy prisoner, who reveals that White has stolen the vaccine and is attempting to flee, while readying to detonate a nuclear explosive to wipe out the island. The group races to the roof and confront White, who refuses to hand over the vaccine. Jin releases White's wife from a restraining harness, forcing White to defend himself. His wife bites him, infecting him, and he shoots both her and Jin before taking the vaccine. However, the vaccine's formula is flawed, and White becomes an inhuman monster, and the group is forced to kill him. The group escapes Banoi in White's helicopter along with Yerema and Kevin, and as they travel to Sydney, ponder the fate of the world.
On July 18, 2006, in a classified location two weeks before the outbreak, Ryder White, a colonel in the Australian Defense Force, is being interviewed by his commanding officer. He was presented with targets which he was asked if he would kill without question (one of which was his wife, Emily White, which he agreed to reluctantly). Behind a one way mirror, two observers discuss Ryder's answer. After passing the test, Ryder was deployed on Banoi in order to aid with containing the recent infection outbreak. During the mission, Ryder and his squad on board of a helicopter were ordered to initiate a bombing run on the highway in the jungle. During their flight back to the base, the co-pilot of the aircraft became infected and attacked the other pilot, forcing the craft to crash land in Moresby. Ryder awakens from the crash several hours later to find himself the only survivor among his crew. He is then contacted by the B.I.D.F. who instruct him to regroup with Unit 4 stationed near Saint Christopher's Church. Ryder arrives at the unit's location to discover that everyone had been killed by the Raskols before being stripped of their weapons and equipment, which included the explosive charges needed to destroy the City Bridge in Sector 4 (Old Town) used to prevent the infection from spreading any further.
He is then informed by the B.I.D.F. to make his way to the Police Station in Sector 3 of the city in order to recover the explosives to complete Unit 4's mission. After fighting his way to the Police Station, Ryder is confronted by members of the gang who taunt him over the loss of his fellow soldiers. After a heated firefight, Ryder managed to kill the gang members and collected the stolen equipment before being instructed to proceed with finding and destroying the bridge. With most of the roadways blocked, Ryder climbed into a manhole that took him to the sewers beneath Moresby in order to gain access to the riverside. Upon exiting the sewers, Ryder's progress is again faltered by the Raskols gang and claim the City Bridge as their territory; leaving him with no other option but to kill them. Later, Ryder proceeded placed charges on the bridge and set it to explode. With the mission a success, the B.I.D.F. intel ordered Ryder to make his way to the evacuation zone in Sector 6 (Gas Station). Ryder then fought through waves of Infected as he waited for the evac chopper to arrive. While on board the chopper, Ryder contacted Emily telling her to prepare herself to be picked up. Emily however, replied that she had been bitten and told Ryder to go on without her before making her tearful farewell to him. Unable to accept the loss of his wife, Ryder ordered the pilot not to land on the aircraft carrier off the coast of the island and instead change course to the Prison in order to pick up his wife. The chopper then landed on the roof of the prison where Ryder ran his way inside to find Emily in hopes of not being too late.
When Ryder reaches Emily in the hospital wing of the prison, he finds her strapped to a bed trying to tell him to leave her in broken English as a result of the gradual transformation into an Infected. Ryder then travels deeper into the prison in order to find Kevin. Upon discovering Kevin, he discovers that Kevin is actually the terrorist, Charon. Ryder was then left with no other choice but to collaborate with Charon in order to ensure his wife's life. Charon instructed Ryder to active the prison's emergency power in order to activate the complex's surveillance cameras which Charon would then use to guide Ryder. Once the power was back online, Ryder was confronted by a groups of rebel prisoners that managed to obtain firearms from the prison's armory. After fighting through numerous groups of prisoners, Ryder arrived at one of the other medical wards in the hospital where he found an antibiotic, Tetracycline, to slow the effects of the Infection on Emily. Once Ryder obtained the antibiotic, Charon informed him that the Heroes were on their way to the island with the antidote and that the antibiotic would slow down the effects of the Infection on Emily until they arrived.
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