Continuing through the marshlands, they find Josh injured but safe, and with his help track down Irving's boat. Irving injects himself with a variant of the parasite, Las Plagas, and mutates into a colossal octopus-like beast. Chris and Sheva defeat him, and with his dying words, directs the pair to a nearby cave to learn more. The cave, home of the Ndipaya tribe, is the source of the flower used to create the Progenitor virus, which led to the creation of the T- and G-viruses. Chris and Sheva find evidence that Tricell, the company funding the BSAA, had taken over a former Umbrella underground laboratory and continued Umbrella's research. In the facility are thousands of capsules holding human test subjects. Chris discovers one of the capsules belongs to Jill, but when they search it, they find the capsule empty. As they leave, they discover Tricell agent Excella Gionne has been plotting with Wesker to unleash a number of missiles with the Uroboros virus across the globe. Chris and Sheva pursue Excella, but are stopped by Wesker and the hooded figure, later revealed to be Jill, enslaved by a mind-control device on her chest. Excella and Wesker escape to a Tricell oil tanker while Chris and Sheva fight Jill, eventually subduing her and removing the device from her chest. After a brief reunion, Jill orders Chris to follow Wesker.
As Chris and Sheva make their way aboard the tanker, they come across Excella, who escapes, but drops a case of syringes. Sheva holds on to a number of them. When Chris and Sheva arrive on the main deck of the tanker, Wesker, through the tanker's intercom, reveals he has betrayed and infected Excella with Uroboros. She mutates into a giant monster which Chris and Sheva eventually defeat. Jill radios in and informs Chris and Sheva that Wesker must regularly take precisely measured doses of a drug to maintain his superhuman strength and speed; a larger or smaller dose would act as poison for Wesker. Sheva then realizes the syringes she recovered from Excella are doses of that drug. Chris and Sheva follow Wesker to a bomber aboard the tanker loaded with missiles containing the Uroboros virus. Eventually, the two are able to subdue Wesker long enough to inject him with additional doses. Wesker attempts to escape on the bomber, but is followed by Chris and Sheva who disable the bomber, causing it to crash land in a volcano. An enraged Wesker exposes himself to Uroboros, and pursues Chris and Sheva through the volcano. Chris and Sheva fight and weaken Wesker to the point where he falls into the lava. They are then rescued by a helicopter piloted by Jill and Josh. In his dying breaths, Wesker attempts to drag the helicopter into the volcano, but Chris and Sheva kill him with Rocket-propelled grenades,[16] before he is able to do so. In the final cutscene of the game, Chris ponders whether it is truly worth fighting to preserve what is left of humanity. He looks at Sheva and Jill and decides that it is worth it in order to live in a world without fear.
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